Hydrogen-bond-promoted palladium catalysis: allylic alkylation of indoles with unsymmetrical 1,3-disubstituted allyl acetates using chiral bis (sulfoxide) phosphine ligands

Du, L.; Cao, P.; Xing, J.; Lou, Y.; Jiang, L.; Li, L.; Liao, J.

Angewandte Chemie 52(15): 4207-4211

ISSN/ISBN: 1521-3773

2013

PMID: 23463674
DOI: 10.1002/anie.201209485
Document: 001908584

A Dykat die hard: A new class of chiral Bi SO-P ligands were effective for an unprecedented palladium-catalyzed asymmetric allylic alkylation of indoles with the racemic title acetates through a dynamic kinetic asymmetric transformation (DYKAT). The hydrogen bond formed between the sulfinyl group of the ligand and Nh of indole plays an important role in the reaction.

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