Advances in Stereoconvergent Catalysis from 2005 to 2015: Transition-Metal-Mediated Stereoablative Reactions, Dynamic Kinetic Resolutions, and Dynamic Kinetic Asymmetric Transformations

Bhat, V.; Welin, E.R.; Guo, X.; Stoltz, B.M.

Chemical Reviews 117(5): 4528-4561

ISSN/ISBN: 1520-6890

2017

PMID: 28164696

DOI: 10.1021/acs.chemrev.6b00731

Document: 007242327

Stereoconvergent catalysis is an important subset of asymmetric synthesis that encompasses stereoablative transformations, dynamic kinetic resolutions, and dynamic kinetic asymmetric transformations. Initially, only enzymes were known to catalyze dynamic kinetic processes, but recently various synthetic catalysts have been developed. This Review summarizes major advances in nonenzymatic, transition-metal-promoted dynamic asymmetric transformations reported between 2005 and 2015.